Cortical Plasticity Study

Cortical plasticity studies investigate how the cerebral cortex changes its structure, function, and connectivity in response to experience, learning, injury, or altered sensory input. These changes arise when activity-dependent mechanisms modify synaptic strength, reorganize cortical representations, and recruit or refine neural pathways. Researchers use methods such as behavioral testing, sensory stimulation, neuroimaging, electrophysiology, and lesion or rehabilitation models to measure these adaptations. Findings help explain skill acquisition, recovery after stroke or trauma, and developmental changes, while informing therapies designed to support functional reorganization and improve outcomes in neurological disease.

Cortical Plasticity Study - Related Videos

Research

JoVE Journal - Neuroscience

Standardized Induction and Assessment of Long-term Potentiation-like Cortical Plasticity Using Transcranial Magnetic Stimulation

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2025

This paper describes the standardized induction of Long-term Potentiation-like cortical plasticity using repetitive stimulation protocols, followed by applying single-pulse transcranial magnetic stimulation guided by a neuronavigation system to evaluate synaptic plasticity.

Forming Micro-and Nano-Plastics from Agricultural Plastic Films for Employment in Fundamental Research Studies

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Cited by 3 •

2022

We show the formation and dimensional characterization of micro- and nanoplastics (MPs and NPs, respectively) using a stepwise process of mechanical milling, grinding, and imaging analysis.

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

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Cited by 4 •

2024

Here, we present the acute genetic manipulation of sliced human cortical organoids by electroporation. These cortical organoid models are particularly amenable to injection as ventricle-like structures can be readily identified after slicing, enabling the functional investigation of human cortical development, neurodevelopmental disorders, and cortical evolution.

Research

JoVE Journal - Medicine
Free Sample

Study Design for Navigated Repetitive Transcranial Magnetic Stimulation for Speech Cortical Mapping

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Cited by 4 •

2023

Navigated repetitive transcranial magnetic stimulation is a highly efficient non-invasive tool for mapping speech-related cortical areas. It helps in designing brain surgery and speeds up the direct cortical stimulation conducted during the surgery. This report describes how to perform speech cortical mapping reliably for preoperative evaluation and research.

Ex utero Electroporation and Whole Hemisphere Explants: A Simple Experimental Method for Studies of Early Cortical Development

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Cited by 14 •

2013

This protocol describes an improved explant procedure that involves ex utero electroporation, dissection and culture of entire cerebral hemispheres from the embryonic mouse. The preparation facilitates pharmacological studies and assays of gene function during early cortical development.

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