Modular Networks

Modular networks are systems organized into groups of densely interconnected nodes, or modules, with fewer connections between groups. In neuroscience, this architecture enables specialized processing within modules while coordinating information across them through intermodule links, balancing functional segregation with global integration. Network scientists identify modules in brain connectivity data using graph-theoretic methods and compare their organization across regions, developmental stages, tasks, or clinical conditions. Studying modular networks helps explain how the brain supports complex cognition, adapts to changing demands, and maintains efficient communication, while also revealing how altered connectivity may contribute to neurological and psychiatric disorders.

Modular Networks - Related Videos

Research

JoVE Journal - Neuroscience

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

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Cited by 6 •

2015

This manuscript describes a protocol to grow in vitro modular networks consisting of spatially confined, functionally inter-connected neuronal circuits. A polymeric mask is used to pattern a protein layer to promote cellular adhesion over the culturing substrate. Plated neurons grow on coated areas establishing spontaneous connections and exhibiting electrophysiological activity.

Standardized Modular Assembly of Polycistronic Operons with Modular Cloning (MoClo) using the In-Cloning toolkit

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2025

This article presents a step-by-step protocol demonstrating how Modular Cloning (MoClo) can be adapted for the cloning of polycistronic operons.

Research

JoVE Journal - Genetics

CRISPR-Based Modular Assembly for High-Throughput Construction of a UAS-cDNA/ORF Plasmid Library

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Cited by 1 •

2024

We present a protocol for CRISPR-based modular assembly (CRISPRmass), a method for high-throughput construction of UAS-cDNA/ORF plasmid library in Drosophila using publicly available cDNA/ORF resources. CRISPRmass can be applied to editing various plasmid libraries.

Robotics in Surgery: A Modular Robotic Platform Driven Gastric Wedge Resection

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2025

Robotically assisted surgery has become highly popular in recent years. Presented here is the standard care for upper gastrointestinal procedures, including a demonstration of a robotic-assisted gastric wedge resection using a modular robotic device.

Education

JoVE Core - Molecular Biology

Protein Networks

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2020

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions. These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

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