Programmable Stimulator
Programmable Stimulator - Related Videos
05:30
Making Patch-pipettes and Sharp Electrodes with a Programmable Puller
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Cited by 22 •
2008
This video shows how to use a programmable puller to make patch pipettes and sharp electrodes for electrophysiology. The same procedure can be used to make a variety of glass tools, including injection needles.
07:34
A Simple Stimulatory Device for Evoking Point-like Tactile Stimuli: A Searchlight for LFP to Spike Transitions
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Cited by 4 •
2014
To elucidate the complex transition from Local Field Potentials (LFPs) to spikes a suitable stimulator for light mechanical peripheral stimuli was built. As an application, the spiking activities recorded from somatosensory cortex were analyzed by a multi-objective optimization strategy. The results demonstrated that the proposed stimulator was able to deliver tactile stimuli with millisecond and millimeter precisions.
11:55
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
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Cited by 9 •
2011
This paper describes a simple technique to induce alloantigen-specific anergy in human peripheral blood mononuclear cells. The technique can be applied clinically to generate non-alloreactive donor cells. Infusion of these cells could improve immune reconstitution and reduce toxicity after allogeneic hematopoietic stem cell transplantation.
10:28
Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials
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Cited by 6 •
2017
This paper presents a series of protocols for developing engineered cells and functionalized surfaces that enable synthetically engineered E. coli to control and manipulate programmable material surfaces.
09:56
Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
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2019
This protocol demonstrates how to use the Auto-CHO software for hierarchical and programmable one-pot synthesis of oligosaccharides. It also describes the general procedure for RRV determination experiments and one-pot glycosylation of SSEA-4.
FAQs
These parameters define the electrical pattern delivered to the preparation and allow investigators to test how different stimulation conditions affect neural responses. Amplitude can be varied alongside frequency, pulse duration, polarity, or timing rather than changed in isolation. Systematic adjustment of these variables helps distinguish response patterns associated with particular stimulation configurations.
Timing determines when electrical input reaches the preparation relative to other experimental events or recorded activity. Researchers can therefore compare responses to differently timed pulses and examine how stimulation relates to circuit function, connectivity, or activity-dependent effects. Precise timing also supports reproducible comparisons across trials and across defined stimulation conditions.
By changing the configured pulse pattern, investigators can examine whether stimulation produces different effects on excitable tissue rather than treating every electrical input as equivalent. The resulting neural or behavioral measurements reveal how stimulation conditions influence activity. This flexibility makes the instrument useful for studying circuit responses as well as broader neuromodulation outcomes.
Researchers first configure the pulse amplitude, frequency, duration, polarity, and timing, then transmit the selected waveform through electrodes positioned near the relevant neural preparation. They vary the stimulation pattern across experimental conditions while recording neural or behavioral responses. Comparing those measurements allows investigators to relate specific pulse configurations to changes in neural function or behavior.
A typical setup includes the programmable stimulator, electrodes, an excitable neural preparation, and a method for recording neural or behavioral responses. Electrode placement depends on the target, which may include a nerve, brain region, or another neural preparation. Together, these elements connect controlled electrical input with measurable experimental outcomes.
This approach is useful when investigators need controlled comparisons among multiple stimulation patterns or want to examine responses across precisely specified conditions. It supports experiments on sensory processing, motor control, neural plasticity, and neuromodulation. The ability to configure and repeat patterns also improves experimental reproducibility while enabling systematic analysis of neural or behavioral effects.
Recorded neural responses can provide evidence about circuit function, connectivity, and activity-dependent effects, while behavioral responses can show how stimulation relates to sensory or motor performance. By comparing outcomes across pulse configurations, researchers can investigate neural plasticity and neuromodulation in addition to immediate responses. The same framework supports studies ranging from sensory processing to motor control.