In Vitro Experiment Model

An in vitro experiment model is a laboratory representation of a biological, chemical, or physical system studied outside its natural environment, allowing researchers to isolate variables and test hypotheses under controlled conditions. It works by placing selected components in a defined setup and regulating factors such as temperature, concentration, pressure, geometry, or applied forces while measuring observable responses. In physics, in vitro models help investigate processes including transport, fluid flow, soft-matter behavior, and interactions at interfaces without the complexity of a complete organism or environment. Their results support quantitative model validation, reveal governing mechanisms, and guide the design of experiments, materials, and biomedical technologies.

In Vitro Experiment Model - Related Videos

Research

JoVE Journal - Bioengineering
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Advanced 3D Liver Models for In vitro Genotoxicity Testing Following Long-Term Nanomaterial Exposure

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Cited by 21 •

2020

This procedure was established to be used for developing advanced 3D hepatic cultures in vitro, which can provide a more physiologically relevant assessment of the genotoxic hazards associated with nanomaterial exposures over both an acute or long-term, repeated dose regimes.

Research

JoVE Journal - Medicine

Use of a Linear Accelerator for Conducting In Vitro Radiobiology Experiments

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Cited by 7 •

2019

Clinical linear accelerators can be used to determine biologic effects of a wide range of dose rates on cancer cells. We discuss how to set up a linear accelerator for cell-based assays and assays for cancer stem-like cells grown as tumorspheres in suspension and cell lines grown as adherent cultures.

Surrogate Model Development for Digital Experiments in Welding

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Cited by 4 •

2025

This protocol outlines a general workflow for constructing an artificial neural network for welding simulation using datasets generated automatically through Python scripts with macro functions. The workflow is validated against a benchmark case involving single-pass, straight-line welding. The surrogate model's predictive accuracy shows a strong agreement with finite element simulations.

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

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Cited by 22 •

2017

Whole organ culture of the intervertebral disc (IVD) preserves the native extracellular matrix, cell phenotypes, and cellular-matrix interactions. Here we describe an IVD culture system using mouse lumbar and caudal IVDs in their functional spinal units and several applications utilizing this system.

An In Vitro Bladder Model of Catheter-Associated Urinary Tract Infection

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Cited by 1 •

2025

This protocol details an in vitro model of the catheterized urinary tract, which can be used to study both planktonic and biofilm-associated bacterial cell populations in simulated catheter-associated urinary tract infections. This model can be further utilized to study the efficacy of antimicrobial products aimed at controlling urinary tract infections.

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