Tissue Cohesion Measurement
Tissue Cohesion Measurement - Related Videos
12:49
Measurement of Aggregate Cohesion by Tissue Surface Tensiometry
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Cited by 10 •
2011
We describe a method of measuring binding energy, expressible as tissue surface tension, between cells within 3D tissue-like aggregates. Differences in tissue surface tension have been demonstrated to correlate with invasiveness of lung, muscle, and brain tumors, and are fundamental determinants of establishing spatial relationships between different cell types.
01:07
Cohesion
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2019
Cohesion is the attraction between molecules of the same type, such as water molecules. Water molecules have an overall neutral charge but are polar molecule. An oxygen atom in one water molecule has a partial negative charge that can bind to a hydrogen atom with a partial positive charge in a second water molecule, forming a hydrogen bond. Each water molecule can form up to four hydrogen bonds with other water molecules. Hydrogen bonds are responsible for water's cohesive nature. On a surface,...
09:10
An Intra-Tissue Radiometry Microprobe for Measuring Radiance In Situ in Living Tissue
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2023
In this paper, a method for measuring radiance in situ in living tissue is described. This work includes details of the construction of micro-scale probes for different measurements of radiance and irradiance, provides guidance for mounting tissue for the characterization of radiance, and outlines computational methods for analyzing the resulting data.
03:13
Lymphedema Ultrasonography: A Technique to Measure the Change in Thickness of an Affected Tissue
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2023
This video utilizes ultrasonography for diagnosis and follow-up tests to determine treatment efficacy of Progressive Resistance Exercise (PRE) in breast cancer-related lymphedema (BCRL). Ultrasonography can be applied effectively to ensure diagnosis and treatment of lymphedema.
02:51
Measuring the Viscoelastic Properties of Mouse Brain Tissue Using Rheometry
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2025
Source: Canovic, E. P., et al. Characterizing Multiscale Mechanical Properties of Brain Tissue Using Atomic Force Microscopy, Impact Indentation, and Rheometry. J. Vis. Exp. (2016)In this video, a rheometer was used to apply controlled oscillatory rotational motion to brain tissue to generate shear strain and evaluate the tissue's viscous and elastic properties. The rheometer, as a functional tool, it provides insights into brain mechanics during injury or neurodegenerative diseases.
FAQs
Each loading mode challenges tissue organization in a different way. Tensile and compression tests assess behavior during pulling or squeezing, while aspiration and shear apply other controlled forms of mechanical stress. Comparing deformation, stress, or failure force across these tests helps bioengineers identify how tissue structure responds under distinct conditions rather than relying on a single mechanical measurement.
Cell-cell interactions help maintain connections among neighboring cells, while cell-matrix interactions link cells to the surrounding extracellular matrix. Their combined strength affects whether a tissue remains organized, deforms under applied force, or fails. Measuring these responses therefore connects a tissue’s mechanical behavior with the underlying organization of its cellular and matrix components.
Deformation describes how much a sample changes shape under an applied force, whereas stress relates the applied force to the tissue response. Failure force indicates the load at which cohesion no longer maintains structural integrity. Together, these outcomes provide complementary information about stability, organization, and mechanical behavior in native or engineered tissue samples.
A typical workflow begins by selecting a tissue sample and applying a controlled tensile, compression, aspiration, or shear force. The resulting deformation, stress, or failure force is then measured and interpreted as evidence of tissue cohesion. Consistent loading conditions allow researchers to compare samples and evaluate how cellular and extracellular organization affects mechanical performance.
Bioengineers apply cohesion measurements when evaluating engineered tissues, organoids, and biomaterial-based constructs. The results show whether a construct has sufficient internal stability and organization for its intended model or design. This information can guide scaffold and culture design by revealing how effectively cellular and matrix interactions support the construct’s mechanical behavior.
Comparing measurements from healthy and diseased tissues can reveal differences in integrity, organization, or mechanical behavior. In regenerative medicine, similar assessments help evaluate whether engineered constructs reproduce important tissue properties. The resulting mechanical information also contributes to developing functional tissue models for drug testing and to refining biomaterial-based strategies.