Gate Valve

A gate valve is a mechanical device that starts or stops fluid flow by moving a barrier, or gate, through a pipeline, making it a fundamental component of fluid-control systems in engineering. When the valve operates, a handwheel, actuator, or stem raises or lowers the gate perpendicular to the flow path; a fully raised gate leaves a nearly unobstructed passage, while a lowered gate seals against valve seats. Gate valves are widely used in water treatment, oil and gas, power generation, and industrial process systems where reliable isolation and low flow resistance are important. They are generally suited to on-off service rather than flow throttling.

Gate Valve - Related Videos

Research

JoVE Journal - Behavior
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P50 Sensory Gating in Infants

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Cited by 5 •

2013

Methods to record auditory P50 sensory gating, a physiological marker of cerebral inhibition which reflects early stages of attention, are described.

Research

JoVE Journal - Biology

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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Cited by 8 •

2021

This article describes the isolation of mouse aortic valve cells by a two-step collagenase procedure. Isolated mouse valve cells are important for performing different assays, such as this in vitro calcification assay, and for investigating the molecular pathways leading to aortic valve mineralization.

Research

JoVE Journal - Medicine

Four-Dimensional Computed Tomography-Guided Valve Sizing for Transcatheter Pulmonary Valve Replacement

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Cited by 6 •

2022

This study assessed a new methodology with a straightened model generated from the four-dimensional cardiac computed tomography sequence to obtain the desired measurements for valve sizing in the application of transcatheter pulmonary valve replacement.

Isolation and Characterization of Primary Rat Valve Interstitial Cells: A New Model to Study Aortic Valve Calcification

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Cited by 17 •

2017

This protocol describes the isolation, culture, and calcification of rat-derived valve interstitial cells, a highly physiological in vitro model of calcific aortic valve disease (CAVD). Exploitation of this rat model facilitates CAVD research in exploring the cell and molecular mechanisms that underlie this complex pathological process.

Education

JoVE Core - Pharmacology
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Ligand-Gated Ion Channel Receptor: Gating Mechanism

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2023

Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...

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