<p class="jove_content">This study describes a rat model for evaluating post-exposure N-acetylcysteine and guarana treatment following acute acetaminophen toxicity. Across the evaluated outcomes, combined treatment produced findings that most consistently approached control values.</p>

hepatoprotective-effects-n-acetylcysteine-guarana-wistar-rat-model

Hepatoprotective Effects of N-Acetylcysteine and Guarana in a Wistar Rat Model of Acute Acetaminophen Toxicity

Acetaminophen overdose causes acute liver injury through oxidative stress, inflammation, and hepatocellular damage. This study evaluated the post-exposure ...

<p class="jove_content">This study compares the nephroprotective effects of ethanol and fomepizole in a methotrexate-pretreated rat model of methanol intoxication designed to reduce folate-dependent formate clearance. Renal outcomes were evaluated using measures of renal function, kidney injury biomarkers, inflammatory markers, redox-related biomarkers, and histopathological findings.</p>

nephroprotective-effects-ethanol-fomepizole-methotrexate-pretreated

Nephroprotective Effects of Ethanol and Fomepizole in a Methotrexate-Pretreated Rat Model of Methanol Intoxication

Methanol intoxication causes metabolic acidosis, organ injury, and death; renal injury predicts adverse outcomes. Ethanol and fomepizole were compared in ...

Institution - Ahi Evran University Faculty of Medicine

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