<p class="jove_content">This study compares the nephroprotective effects of ethanol and fomepizole in a methotrexate-pretreated rat model of methanol intoxication designed to reduce folate-dependent formate clearance. Renal outcomes were evaluated using measures of renal function, kidney injury biomarkers, inflammatory markers, redox-related biomarkers, and histopathological findings.</p>

nephroprotective-effects-ethanol-fomepizole-methotrexate-pretreated

Nephroprotective Effects of Ethanol and Fomepizole in a Methotrexate-Pretreated Rat Model of Methanol Intoxication

Methanol intoxication causes metabolic acidosis, organ injury, and death; renal injury predicts adverse outcomes. Ethanol and fomepizole were compared in ...

Institution - Kirsehir Ahi Evran University Faculty of Medicine

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