<p class="jove_content">Proteomics is a high-throughput assessment of the interactions, function, composition, and structures of proteins and their cellular activities. Here, we present a protocol to assess total proteomic changes in various bio-samples, including plasma and tissues. The methodology reported herein is applicable to all bio-samples containing proteins. </p>

elucidating-tissue-plasma-specific-proteomic-alterations-health

Elucidating Tissue- and Plasma-Specific Proteomic Alterations in Health and Disease

Proteomics is the large-scale study of expressed proteins, focusing on their structure, function, interactions, abundance, and post-translational ...

<p class='jove_content'>Botulinum neurotoxin is one of the most potent toxins among Category-A biothreat agents, yet a post-exposure therapeutic is not available. The high content imaging approach is a powerful methodology for identifying novel inhibitors as it enables multiparameter screening using biologically relevant motor neurons, the primary target of this toxin.</p>

a-high-content-imaging-assay-for-identification-botulinum-neurotoxin

A High Content Imaging Assay for Identification of Botulinum Neurotoxin Inhibitors

Synaptosomal-associated protein-25 (SNAP-25) is a component of the soluble NSF attachment protein receptor (SNARE) complex that is essential for synaptic ...

Institution - The Geneva Foundation

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