<p class="jove_content">The goal of this project is to detail a thoroughly scrutinized protocol of the surgical placement of an ameroid constrictor around the proximal left circumflex coronary artery (LCx), thereby inducing chronic coronary artery disease and precisely mapping the ischemic territory using isotope-labeled microspheres. </p>

a-clinically-relevant-swine-model-chronic-myocardial-ischemia-ameroid

A Clinically Relevant Swine Model of Chronic Myocardial Ischemia by Ameroid Constrictor Placement with Simultaneous Perfusion Mapping

Despite breakthroughs in medical and procedural therapies for the treatment of cardiovascular disease, the need for translational large animal models has ...

<p class="jove_content">The following surgical protocol represents the second and final procedure to thoroughly and reliably characterize the cardiac function and myocardial perfusion after successful induction of chronic myocardial ischemia in a swine model in an effort to investigate novel therapies. </p>

terminal-harvest-procedure-large-animal-model-chronic-myocardial

Terminal Harvest Procedure of a Large Animal Model of Chronic Myocardial Ischemia with Hemodynamic Characterization and Perfusion Analysis

Reproducibility and research integrity are foundational tenets to scientific discovery, which are produced utilizing well-established, proven principles ...

Institution - Rhode Island Hospital

Articles Published in JoVE