Myocardial Strain

Myocardial strain is a quantitative measure of how much heart muscle deforms during the cardiac cycle, providing a sensitive view of myocardial function beyond chamber size or ejection fraction. In bioengineering applications, imaging systems such as speckle-tracking echocardiography follow natural acoustic patterns within the myocardium and calculate length changes in longitudinal, circumferential, and radial directions. Strain measurements help characterize regional contraction, detect subtle dysfunction, and assess conditions such as ischemic or cardiomyopathic disease. They also support treatment monitoring, device evaluation, and computational models that connect tissue mechanics with cardiac performance.

Myocardial Strain - Related Videos

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JoVE Journal - Medicine
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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

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Cited by 187 •

2011

An accurate and practical method to measure parameters like strain in myocardial tissue is of great clinical value, since it has been shown, that strain is a more sensitive and earlier marker for contractile dysfunction than the frequently used parameter EF.

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JoVE Journal - Medicine
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High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

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Cited by 9 •

2010

High frequency Doppler ultrasound is a novel technology for assessing regional myocardial function. This work presents first evidence demonstrating applicability of this versatile imaging platform for the repeated measure of myocardial strain, dp/dt, and mitral regurgitation in the ischemia-reperfused (IR) murine heart.

Research

JoVE Journal - Bioengineering
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Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

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Cited by 8 •

2021

This study describes a comprehensive cardiovascular magnetic resonance imaging (CMR) protocol to quantify the left ventricular functional parameters of the mouse heart. The protocol describes the acquisition, post-processing, and analysis of the CMR images as well as assessment of different cardiac functional parameters.

Research

JoVE Journal - Medicine

Induction of Myocardial Infarction and Myocardial Ischemia-Reperfusion Injury in Mice

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Cited by 11 •

2022

Here we describe a simple and reproducible method that can induce myocardial infarction or myocardial ischemia-reperfusion injury in mice by precision ligation of the left anterior descending coronary artery through micromanipulation.

Measurement of Compressive Stress-Strain Response at Small-Strains

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2025

This protocol presents the configuration of a compression test device capable of precisely measuring the mechanical properties of microstructures in the small-strain region, along with a systematic method for compression testing using this device. The proposed device can be used to analyze various microstructures and the mechanical behavior of polymer-based materials.

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