Muscle Construct
Muscle Construct - Related Videos
01:24
Evaluating Neurite Growth in Bioprinted Skeletal Muscle Constructs with a Microsphere Delivery System
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2025
Take bioprinted skeletal muscle constructs.These constructs contain fibrin hydrogel pillars with embedded muscle fibers and microspheres.The microsphere is a porous polymer structure enclosing neurotrophic factors.Take dorsal root ganglia isolated from chick embryos.Place one ganglion on each construct and incubate.The neurotrophic factors are released from the microspheres at a controlled physiological concentration, facilitating the sprouting of projections from the neurons called...
13:43
Fabrication of Myogenic Engineered Tissue Constructs
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Cited by 11 •
2009
Here, we demonstrate fabrication of collagen-based, tissue constructs containing skeletal myoblasts. These 3-D engineered constructs may be used to replace or repair tissues in vivo. For our purposes, we have designed these as an atrioventricular electrical conduit for the repair of complete heart block[1].
11:47
Construction of a Human Aorta Smooth Muscle Cell Organ-On-A-Chip Model for Recapitulating Biomechanical Strain in the Aortic Wall
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Cited by 1 •
2022
Here, we developed a human aorta smooth muscle cell organ-on-a-chip model to replicate the in vivo biomechanical strain of smooth muscle cells in the human aortic wall.
09:01
Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
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Cited by 2 •
2022
Mitochondria are key metabolic organelles that exhibit a high level of phenotypic plasticity in skeletal muscle. The import of proteins from the cytosol is a critical pathway for organelle biogenesis, essential for the expansion of the reticulum and the maintenance of mitochondrial function. Therefore, protein import serves as a barometer of cellular health.
08:34
Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
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Cited by 59 •
2016
We describe a set of protocols that together provide a tissue-mimicking hydrogel bioink with which functional and viable 3-D tissue constructs can be bioprinted for use in in vitro screening applications.
FAQs
Scaffold architecture and cell alignment help organize muscle cells into a three-dimensional arrangement that more closely reflects native tissue structure. This organization can support differentiation, maturation, and coordinated contraction when combined with appropriate biochemical cues, mechanical loading, or electrical stimulation. In bioengineering studies, controlling alignment therefore helps researchers examine how structural design affects functional muscle behavior.
These inputs provide complementary signals during construct development. Biochemical cues can promote muscle-cell differentiation, while mechanical loading and electrical stimulation can encourage maturation and coordinated contraction. Applying these conditions in a controlled system allows researchers to investigate how engineered muscle responds to different developmental and functional signals rather than relying only on its initial cellular organization.
Three-dimensional models provide a controlled setting in which researchers can examine muscle development, injury, disease-related changes, and responses to drugs. Because the cells and supporting materials are organized in an engineered tissue environment, experiments can focus on defined structural and functional conditions. These models may also reduce reliance on animal experiments while supporting systematic comparison of treatments or biological responses.
A typical design combines muscle cells with a supporting scaffold or hydrogel that embeds or aligns the cells in three dimensions. Researchers can then provide biochemical cues, mechanical loading, and electrical stimulation to encourage differentiation, maturation, and coordinated contraction. The selected combination of materials and conditions determines how closely the engineered tissue reproduces important structural and functional features of native muscle.
Researchers can use these constructs to investigate how muscle develops, responds to injury or disease, and reacts to drug exposure. Their organized cellular structure and capacity for coordinated contraction provide functional context alongside tissue-level observations. As a result, the models can reveal effects that may be difficult to study in isolated cells while maintaining controlled experimental conditions.
In regenerative medicine, engineered muscle tissues help inform the design of implantable constructs and strategies for restoring strength and function after muscle damage. Findings from controlled models can guide decisions about cellular organization, supporting materials, and stimulatory conditions. This application connects bioengineering studies of muscle development and maturation with longer-term efforts to repair or replace injured tissue.