Spatial Context
Spatial Context - Related Videos
08:52
Spatial Molecular Imaging of the Glycome Using Mass Spectrometry
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Cited by 1 •
2025
This protocol details the key steps to enable rigorous and reproducible measurement of both glycogen and N-linked glycans using mass spectrometry imaging.
07:51
Spatial Cueing
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2023
Source: Laboratory of Jonathan Flombaum—Johns Hopkins University Attention refers to the limited human ability to select some information for processing at the expense of other stimuli in the environment. Attention operates in all sensory modalities: vision, hearing, touch, even taste and smell. It is most often studied in the visual domain though. A common way to study visual attention is with a spatial cueing paradigm. This paradigm allows researchers to measure the consequences of focusing...
10:16
Mining Spatial Transcriptomics Datasets using DeepSpaceDB
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2025
This article introduces a protocol for using DeepSpaceDB, a dynamic, interactive database for spatial transcriptomics, offering analysis workflows and examples to explore tissue organization and disease-related gene expression.
01:30
Self Within Cultural Contexts
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2025
Cultural frameworks for understanding the self are often categorized into two broad orientations: individualism and collectivism. These paradigms influence how people define themselves, relate to others, and interpret their social worlds. Each orientation offers distinct perspectives on autonomy, responsibility, and the role of the individual within a community.Individualistic CulturesIn individualistic cultures like North America and Western Europe, identity is understood as autonomous and...
07:40
Spatially Compact Arrangement of Larval Zebrafish Sections for Spatial Transcriptomic Analysis
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2025
Here, we present a method for aligning and cryosectioning multiple Zebrafish (Danio rerio) larvae samples and collecting them on a single slide for spatial transcriptomic analysis.
FAQs
Spatial context reveals more than where a component is located: it connects position with biological behavior. A signal gradient, for example, can guide cells differently across a tissue, while local mechanical forces may alter how cells grow or repair. Examining these relationships helps bioengineers interpret tissue function as an organized system rather than as isolated cellular events.
Neighboring cells can respond to one another because proximity places them within a shared local environment of signals and forces. Their arrangement therefore affects how communication is interpreted and how growth or repair proceeds. In engineered tissues, preserving or deliberately changing these local relationships can reveal which architectural features are important for reproducing native biological organization.
Spatial patterning creates defined arrangements, whereas controlled microenvironments regulate conditions around cells, biomaterials, signals, or forces. Imaging can then be used to examine where those components appear and how they relate across a tissue. Combining these approaches gives researchers ways to test whether a designed spatial organization produces the growth, communication, or repair behavior they seek.
A spatial-context study can begin by mapping the positions of cells, biomaterials, signals, and mechanical forces across a tissue. Researchers may use imaging, spatial patterning, or controlled microenvironments to examine those relationships. The resulting map is interpreted alongside tissue behavior, such as communication, growth, or repair, so architecture and function can be considered together.
On organ-on-a-chip platforms, spatial context helps researchers consider how cells, signals, biomaterials, and forces are arranged within the model. This matters because the platform is intended to reproduce aspects of physiology, not merely place cells in a container. Analyzing location and relationships can therefore improve interpretation of chip behavior and support more physiologically relevant engineered systems.
In regenerative medicine, spatial information can guide the design of materials and tissue constructs that better reproduce native biological organization. Engineers can evaluate whether cells encounter neighboring components, signals, and mechanical conditions across the construct. This perspective links material or architectural design to tissue growth and repair, helping explain why organization may influence the behavior of an engineered replacement.